Since December 2013, Biokit has implemented an innovative technology for the large-scale production of recombinant proteins obtained in Baculovirus systems. This methodology is called IBES® Improved Baculovirus Expression System ⁽¹⁾

Biokit offers its Large-Scale Baculovirus Expression System Service for the development and manufacturing of high quality recombinant proteins.

IBES® uses an in vivo expression system in which insect larvae are used as living bioreactors, being an efficient system to produce functional recombinant proteins. Caterpillars (larvae) of Trichoplusia ni, a moth with billions of cells, are used to efficiently produce a broad range of complex recombinant proteins. IBES® is an excellent system for producing recombinant proteins, with clear advantages over the more traditional expression systems (E. coli, yeast, insect cell culture, etc.).

Some of the advantages include:

• Large production capability
• Significantly shortened production time
• Flexibility
• Linear scaling-up of production (from mg to kg levels)
• High batch-to-batch reproducibility
• Optimal recombinant protein conformation
• Cost reduction in fixed investments

The final quality of the recombinant protein and the amount obtained meet the most demanding levels of the pharmaceutical and IVD industries. Using IBES® technology, we will be able to supply you with the amount of recombinant protein you require. We can also scale up your manufacturing expression procedure and implement your purification and characterisation processes in our facilities.

⁽¹⁾ IBES is a technology licensed by ALGENEX S.L