Biomaterials for IGFBP-3 immunoassay development & manufacturing

Insulin Growth Factor Binding Protein 3 (IGFBP-3) is a protein found in circulation and inside cells. It is composed of 264 amino acids and has a molecular weight ranging from 28.7 kDa to 53 kDa[1]. IGFBP-3 belongs to the family of insulin growth factor binding proteins, which includes six major types, from IGFBP-1 to IGFBP-6. The expression of both IGFBP-3 and IGF-1 is stimulated by growth hormone (GH), which encompasses the secretion of IGF-1 to circulation and its binding with IGFBP-3[2].

IGFBP-3 is the most prevalent type in human adult serum and is primarily produced in the liver and other peripheral tissues before being secreted into the bloodstream[2]. IGFBP-3 binds mainly to insulin growth factors (IGFs), acting as a transport protein. It prolongs the half-life of IGFs and regulates their removal from circulation[3].

In clinical laboratory, serum levels of IGFBP-3 are considered useful aid in the diagnosis and monitoring of growth-hormone related clinical conditions like acromegaly and growth hormone deficiency [4].

How Werfen can support you

We can support your immunoassay portfolio expansion in the endocrinology panel by providing specifically designed antibodies to detect IGFBP-3.

Werfen endocrinology portfolio consist of the following products.